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Comparison of 2 techniques using EUS guided Liver biopsies via 19g CORE biopsy needle to Obtain Optimal Core Liver Biopsies in Benign Disease

Objective a. To determine if there is a significant difference in pathological yield as determined by fragmentation, length and number of portal tracts of the biopsy sample between a modified wet suction, and a slow pull techniques in obtaining CORE of histologic tissue from nonmalignant liver per EUS. Secondary Objective a. To identify complications within one week that are associated with each technique. b. To identify the time required for each step of the individual procedures. c. To identify additional findings of the procedure not related to liver disease d. To identify any diagnostic differences in pathological findings between left and right liver lobe specimens

Objective a. To determine if there is a significant difference in pathological yield as determined by fragmentation, length and number of portal tracts of the biopsy sample between a modified wet suction, and a slow pull techniques in obtaining CORE of histologic tissue from nonmalignant liver per EUS. Secondary Objective a. To identify complications within one week that are associated with each technique. b. To identify the time required for each step of the individual procedures. c. To identify additional findings of the procedure not related to liver disease d. To identify any diagnostic differences in pathological findings between left and right liver lobe specimens